The volume of clinical research is increasing exponentially—far beyond our ability to process and absorb the results. Given this situation, it may be beneficial to consider reducing the flow at its source. In what follows, I will motivate and critically evaluate the following proposal: researchers should conduct fewer clinical trials. More specifically, I c onsider whether researchers should be permitted to conduct only clinical research of very high quality and, in turn, whether research ethics committees should prohibit all other, lower-quality (...) research, even when it might appear to meet some minimal ethical standard. Following a close analysis of the social-value requirement of ethical clinical research, I argue that this proposal is defensible. The problem identified in this paper has two parts, quantity and quality, and some clarification is needed about the latter because “quality” is a highly contested term in the medical literature. When some scholars advocate for high-quality trials, they mean large-scale, simple, explanatory randomized controlled trials. Others, including myself, have defended a different characterization of high-quality research that tends more toward pragmatic trial design and the use of methods other than RCTs. Pragmatic trials aim to provide evidence that directly supports clinical decision-making in “usual” care settings. Unlike explanatory trials, which aim to abstract away from particular settings and patients, in the hopes of creating ideal conditions for the success of an intervention, pragmatic trials deliberately pursue knowledge of high applicability, through the use of representative subjects, clinically important questions, flexible treatment protocols, patient-oriented outcome measures, and so on. I see applicability as a marker of high-quality research. The context in which research is meant to be applied should be the context in which new interventions are evaluated. (shrink)

In this essay, I defend a mind-body dualism, according to which human minds are immaterial substances that exercise non-redundant causal powers over bodies, against the notorious problem of psychophysical causation. I explicate and reply to three formulations of the problem: (i) the claim that, on dualism, psychophysical causation is inconsistent with physical causal closure, (ii) the claim that psychophysical causation on the dualist view is intolerably mysterious, and (iii) Jaegwon Kim’s claim that dualism fails to account for causal pairings. Ultimately, (...) I conclude that these objections fail and that dualist interactionism is no more problematic or mysterious than physical causation. (shrink)

To meet the luck objection to incompatibilism, philosophers such as Timothy O’Connor, Randolph Clark, and William Rowe resurrected the Reidian notion of agent causation, which implies the “Substance-Causal Thesis” (SCT): some causes are fundamentally substances, not events. I examine an objection to SCT by C. D. Broad, developed by Carl Ginet, that substances cannot cause events because substances cannot explain why events happen when they do. The objection fails as it rests on a demand for contrastive explanations of free actions. (...) However, I show that a slightly different objection succeeds in showing SCT false. (shrink)

This paper discusses the ecological case for epistemic innocence: does biased cognition have evolutionary benefits, and if so, does that exculpate human reasoners from irrationality? Proponents of ‘ecological rationality’ have challenged the bleak view of human reasoning emerging from research on biases and fallacies. If we approach the human mind as an adaptive toolbox, tailored to the structure of the environment, many alleged biases and fallacies turn out to be artefacts of narrow norms and artificial set-ups. However, we argue that (...) putative demonstrations of ecological rationality involve subtle locus shifts in attributions of rationality, conflating the adaptive rationale of heuristics with our own epistemic credentials. By contrast, other cases also involve an ecological reframing of human reason, but do not involve such problematic locus shifts. We discuss the difference between these cases, bringing clarity to the rationality debate. (shrink)

In this opening chapter, we review the literature on information quality. Our major aim is to introduce the issues, and trace some of the history of the debates, with a view to situating the chapters in this volume – whose authors come from different disciplines – to help make them accessible to readers with different backgrounds and expertise. We begin in this section by tracing some influential analyses of IQ in computer science. This is a useful basis for examining some (...) examples of developing work on IQ in section two. We look at some cases for applying IQ in section three, and conclude with some discussion points in section four. (shrink)

Editors' introduction to 3rd thematic issue on philosophy of medicine.

The thesis explores and suggests a solution to a problem that I identify in John McDowell’s and Lynne Rudder Baker’s approaches to mental and intention-dependent (ID) causation in the physical world. I begin (chapter 1) with a brief discussion of McDowell’s non-reductive and anti-scientistic account of mind and world, which I believe offers, through its vision of the unbounded conceptual and the world as within the space of reasons, to liberate and renew philosophy. However, I find an inconsistency in McDowell’s (...) criticism of Davidson’s anomalous monism (chapter 2), stemming from a tension between McDowell’s naïve common sense view of mental causation and an understanding of ordinary physical causation which I think McDowell ought to embrace, which portrays it as both objective, in the sense of being recognition- independent, and as belonging within the space of reasons. The question of the relation between these two concepts of causation is an aspect of the more general question of the relation between the space of reasons and the realm of law. In chapter 3 I begin examining the possibility that Baker’s account of material and property constitution could form the basis of a bridge between the two spaces, and find it generally promising. However, I find that her defence of her version of non-reductive monism against Kim’s causal arguments also runs into problems, which I attribute to the fact that she holds a view of causation as secondary to causal explanation. 2 3 In chapter 4 I develop an account of what I call manifest physical causation – of objective causal relations in the world of Sellars’s manifest image. Based upon McDowell’s transcendental empiricism, which takes the existence of the ordinary perceived world as a condition of the possibility of our possession of conceptual capacities, I contend that it is this picture of reality, rather than that of fundamental physics, that should be the starting point of our theorizing. Causation in the manifest image, I argue, covers the behaviour of the familiar physical world as well as that of its well-understood extensions into the special sciences and engineering. Manifest physical causation, on my account, is productive, acts through mechanisms which are almost entirely mechanical, electromagnetic, and/ or chemical, and is causally closed. In my view, normative, semantic, contentful property-instances are not part of the manifest physical causal nexus. In my final chapter I suggest a modification of Baker’s constitution account, which I call Constituted Causation, whereby higher-level – mental and other ID – causal relations are constituted, in favourable circumstances, by lower-level ones. ID causal relations belong in their own causal nexus but are connected to the manifest physical world through constitution, a relation of unity without identity. Causation and constitution are, respectively, intra- and inter-level relations, and they are non-overlapping. The constituted network of rational and normative relations bears, I believe, striking parallels with McDowell’s view of reality. According to Baker’s view of constitution, the essential properties of constituted entities subsume those of their constituters; extending this to my account enables us to say that the real cause and explanation of someone’s action is that they consciously performed it 4 rather than that certain manifest causal processes occurred at the lower level. (shrink)

The objective of Working Group 4 of the COST Action NET4Age-Friendly is to examine existing policies, advocacy, and funding opportunities and to build up relations with policy makers and funding organisations. Also, to synthesize and improve existing knowledge and models to develop from effective business and evaluation models, as well as to guarantee quality and education, proper dissemination and ensure the future of the Action. The Working Group further aims to enable capacity building to improve interdisciplinary participation, to promote knowledge (...) exchange and to foster a cross-European interdisciplinary research capacity, to improve cooperation and co-creation with cross-sectors stakeholders and to introduce and educate students SHAFE implementation and sustainability. To enable the achievement of the objectives of Working Group 4, the Leader of the Working Group, the Chair and Vice-Chair, in close cooperation with the Science Communication Coordinator, developed a template to map the current state of SHAFE policies, funding opportunities and networking in the COST member countries of the Action. On invitation, the Working Group lead received contributions from 37 countries, in a total of 85 Action members. The contributions provide an overview of the diversity of SHAFE policies and opportunities in Europe and beyond. These were not edited or revised and are a result of the main areas of expertise and knowledge of the contributors; thus, gaps in areas or content are possible and these shall be further explored in the following works and reports of this WG. But this preliminary mapping is of huge importance to proceed with the WG activities. In the following chapters, an introduction on the need of SHAFE policies is presented, followed by a summary of the main approaches to be pursued for the next period of work. The deliverable finishes with the opportunities of capacity building, networking and funding that will be relevant to undertake within the frame of Working Group 4 and the total COST Action. The total of country contributions is presented in the annex of this deliverable. (shrink)

In debates concerning the consequence argument, it has long been claimed that [McKay, T. J., and D. Johnson. 1996. “A Reconsideration of an Argument Against Compatibilism.” Philosophical Topics 24 (2): 113–122] demonstrated the invalidity of rule (β). Here, I argue that their result is not as robust as we might like to think. First, I argue that McKay and Johnson's counterexample is successful if one adopts a certain interpretation of ‘no choice about’ and if one is willing to (...) deny the conditional excluded middle principle. In order to make this point I demonstrate that (β) is valid on Stalnaker's theory of counterfactuals. This result is important and should not be neglected, I argue, because there is a particular line of objection to the revised formulations of the consequence argument that does not succeed against the original version. (shrink)

Phyllis Illari & Federica Russo: Causality: Philosophical Theory Meets Scientific Practice. Oxford: Oxford University Press, 2014, 310pp, £29.99 HB.

In this paper I explore Phyllis Rooney’s 2003 chapter, “Feminist Epistemology and Naturalized Epistemology: An Uneasy Alliance,” taking guidance from her critique of naturalized epistemology in pursuing my own analysis of another uneasy alliance: that between feminist epistemology and social epistemology. Investigating some of the background assumptions at work in prominent conceptions of social epistemology, I consider recent analyses of "epistemic bubbles" to ask how closely such analyses are aligned with ongoing research in feminist epistemology. I argue that critical (...) feminist insights in political philosophy are called for here, especially those that focus on multiple politically salient relationships and also emphasize practices of personal transformation as inseparably bound up with broader movements for social transformation. Insofar as feminist epistemology continues to carry another world in its heart, I argue that it will continue to rest uneasily with any effort to align it with—let alone subsume it within—the still emerging field of social epistemology. (shrink)

Corlett (2019) raises two groups of challenges against the two-factor theory of delusions: One focuses on weighing “the evidence for … the two-factor theory”; the other aims to question “the logic of the two-factor theory” (p. 166). McKay (2019) has robustly defended the two-factor theory against the first group. But the second group, which Corlett believes is in many aspects independent of the first group and Darby (2019, p. 180) takes as “[t]he most important challenge to the two-factor theory (...) raised by Dr. Corlett”, has by large remained. Here I offer my two cents in response to the second group. More specifically, I argue that Corlett’s challenges to the logic of the two-factor theory, concerning modularity, double dissociation and cognitive penetration, seem to be based on some misunderstandings of the two-factor theory. (shrink)

In psychiatry some disorders of cognition are distinguished from instances of normal cognitive functioning and from other disorders in virtue of their surface features rather than in virtue of the underlying mechanisms responsible for their occurrence. Aetiological considerations often cannot play a significant classificatory and diagnostic role, because there is no sufficient knowledge or consensus about the causal history of many psychiatric disorders. Moreover, it is not always possible to uniquely identify a pathological behaviour as the symptom of a certain (...) disorder, as disorders that are likely to differ both in their causal histories and in their overall manifestations may give rise to very similar patterns of behaviour. -/- Consider delusions as an example. It wouldn’t be correct to define delusions as those beliefs people form as a result of a neurobiological deficit and a hypothesis-evaluation deficit (as some versions of the two-factor theory of delusions suggest), because for some delusions no neurobiological deficit may be found, and reasoning biases and motivational factors may be contributors to the formation of the delusion (e.g. McKay et al., 2005). Moreover, it would be a mistake to define delusions as symptoms of schizophrenia alone, because they occur also in other disorders, including dementia, amnesia, and delusional disorders. Thus, aetiological considerations may appear in the description and analysis of delusions, but do not feature prominently in their definition. -/- In this paper I argue that the surface features used as criteria for the classification and diagnosis of disorders of cognition are often epistemic in character. I shall offer two examples: confabulations and delusions are defined as beliefs or narratives that fail to meet standards of accuracy and justification. Although classifications and diagnoses based on features of people’s observable behaviour are necessary at these early stages of neuropsychiatric research, given the variety of conditions in which certain phenomena appear, I shall attempt to show that current epistemic accounts of confabulations and delusions have limitations. Epistemic criteria can guide both research and clinical practice, but fail to provide sufficient conditions for the identification of delusions and confabulations, and fail to demarcate pathological from non-pathological narratives or beliefs. -/- Another limitation of current epistemic accounts – which I shall not address here – is the excessive focus on epistemic faults of confabulations and delusions at the expense of their epistemically neutral or advantageous features (see Bortolotti and Cox, 2009). This may lead to a misconception of delusions and confabulations, and to an oversimplification in the assessment of the needs of people who require clinical treatment for their psychotic symptoms. (shrink)

Introduction: Over the past twenty-five years the sporting body has been studied in a myriad of ways including via a range of feminist frameworks (Hall 1996; Lowe 1998; Markula 2003; George 2005; Hargreaves 2007) and gender-sensitive lenses (e.g. McKay 1994; Aoki 1996; Woodward 2008). Despite this developing corpus, studies of sport only rarely engage in depth with the ‘flesh’ of the lived sporting and exercizing body (Wainwright and Turner 2003; Allen-Collinson 2009) at least from a phenomenological angle, and in (...) relation to female embodiment. It seems that a more corporeally-grounded, phenomenological perspective on women’s sporting embodiment would be a welcome addition to extant studies. In this chapter I suggest that employing a feminist phenomenological framework can provide a powerful lens through which to explore the subjective, richly-textured, lived-body experiences of sport and exercise. Phenomenology of course offers only one of a multiplicity of avenues to investigate the body in sport, and this chapter provides just a small glimpse of its possibilities. To-date studies of sporting experience employing a phenomenological theoretical framework remain surprisingly under-developed (Kerry and Armour 2000), as do those using its ethnomethodological offspring (Coates 1999; Burke et al. 2008). Further, as Fisher (2000) notes, the significance of the interaction between phenomenology and feminism has only relatively recently begun to be explored. It seems timely, therefore, to address this intriguing, potentially productive, but sometimes uneasy nexus, focusing upon female running embodiment in this case. (shrink)

This volume brings together new work on the logic and ontology of plurality and a range of recent articles exploring novel applications to natural language semantics. The contributions in this volume in particular investigate and extend new perspectives presented by plural logic and non-standard mereology and explore their applications to a range of natural language phenomena. Contributions by P. Aquaviva, A. Arapinis, M. Carrara, P. McKay, F. Moltmann, O. Linnebo, A. Oliver and T. Smiley, T. Scaltsas, P. Simons, and (...) B.-Y. Yi . (shrink)

Although it makes some progress, McKay & Dennett's (M&D's) proposal is limited because (1) the argument for adaptive misbelief is not new, (2) arguments overextend the evidence provided, and (3) the alleged sufficient conditions are not as prohibitive as suggested. We offer alternative perspectives and evidence, including individual differences research, indicating that adaptive misbeliefs are likely much more widespread than implied.

What do we do with Judges? This two-edged word? This ambidextrous book? These ambivalent heroes? The Judges were drawing their last fleeting breaths shipwrecked and scattered upon the shores of historical-critical-grammatical-linear-modernist-masculine interpretation. "The narrative is primitive," they said. "The editors have made a mess," they exclaimed. "The conclusion is really an appendix," another said. Then the bible-acrobats jumped in pretending there was no literary carnage while at the same time drawing our eyes away from the literary carnage. "No, no, there (...) is an order to this disorderly book!" "Gideon is a man of faith," they explained. "Gideon is a sham," others retorted. "Long live the king," they cried. "Oh no, the king will bring down the nation," others said. Enter the latest literary critics and the fresh feminist readers to save the day. And save they have. Barry noted the irony. Cheryl called attention to the elaborate, spiraling labyrinth. Phyllis remembered the forgotten. Mieke heralded the incoherence. Deborah the Bee slings Barak with irony. Cowardly Jephthah sacrifices his virgin daughter immediately after he is filled with the spirit. Blind Samson remains stuck in some adolescent, Pinnochio-like stage milling around the same old vices. The Levite, the man of word and sacrifice, lies to the people and dismembers his wife. To beat it all the myopic narrator joins in lock step with the other blind characters stumbling around in the narrative. What manner of text is this? These Judges, these stories, are even more troubling now that we take them seriously. Now what do we do with Judges? The recent scholarship is most promising, but I think we must press forward, or is that backward, or perhaps to another plan. Perhaps Judges hearkens forward to the postmodern. What would Judges look like if we viewed the story through a postmodern lens? Would we see the text in another dimension? Would we let the characters live and breathe as confusing, confounding, intricate characters? Judges speaks to me. These judges, they teach me. How can I ever forget my reading of Judges? For once I found a text reflecting the madness of faith in my maddening world. For once I saw a text like Pablo. I heard the echo of Umberto. I noted the faint murmurings of Jacques. I danced a most joyous jig with Julia. I saw, up ahead, or was that behind me, or over to the side, Martin's flickering candle. Mieke, meet Jael. Barak, meet Barry. Jacques, meet Gideon. Samson, meet Martin. Umberto, meet the narrator or two or three. Pablo, meet the Levite's wife---sorry, she has no name. (shrink)